Anti-idiotypic and Neutralizing Antibodies
MBS has extensive experience developing highly sensitive and specific anti-idiotypic (anti-Id) antibodies to support the development of monoclonal antibody drugs.
Monitoring therapeutic antibodies in clinical samples requires the ability to differentiate between administered antibody and naturally-occurring endogenous antibodies. This has become increasingly difficult as antibody biotherapeutics more closely resemble circulating human immunoglobulins. Anti-idiotypic antibodies specific for the unique variable region of the therapeutic antibody are ideal for this purpose.
Often our customers develop anti-idiotypic antibodies as controls for antibody neutralization assays. Anti-Id antibody candidates are screened for the ability to neutralize or block specific ligand binding of a therapeutic antibody. MBS has a proven track record of achieving successful outcomes with higher complexity projects. Our ability to work closely with customers to clearly understand their end application, define their specific project goals and design a detailed project plan are the keys to our high success rate delivering quality anti-idiotype antibodies.
Common Applications of Anti-Idiotypic Antibodies:
- Preclinical research of therapeutic antibodies
- Anti-drug Antibodies (ADA) for clinical development
- Pharmacokinetic (PK) studies
- Immune Response (IR) immunogenicity assays
- Controls in ligand binding neutralizing assays
- Controls in antibody blocking assays
Contact us for a custom anti-idiotypic antibody development quote today.