Quantity: 250ug $210.00 1mg $300.00
MAB222P Monoclonal Antibody to Human Osteopontin
Background Human Osteopontin (OPN) is a negatively charged, hydrophilic protein of 314 amino acids and is subject to significant post translational modifications. OPN is cleaved by members of the matrix metalloproteinase family (MMP) which results in the generation of N-terminal and C-terminal OPN fragments. The newly exposed SVVYG epitope on the N-terminal fragment has been shown to participate in cell adhesion1.
Clone Determination 14C08
Host OPN Knockout Mouse
Immunogen DSVVYG peptide conjugated to KLH
Immunoglobulin Class IgG1 κ
Specificity Recognizes native human OPN from purified breast milk. Specific for the MMP cleavage site, DSVVYG, of human OPN.
Purification Protein A chromatography from in vitro production
Buffer 0.15M PBS
Applications ELISA- sandwich and indirect, Pairs well with MAB193P
Storage Store at -20C to -80C; avoid repeat freeze- thaw cycles
1Expression and characterization of recombinant osteopontin peptides representing matrix metalloproteinase proteolytic fragments
(2004) Matrix Biology, 23 (7), pp. 457-466.
FOR RESEARCH AND IN VITRO USE ONLY
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